Mass spectrometry in drug metabolism and disposition basic principles and applications /
"This book examines the background, industrial context, process, analytical methodology, and technology of metabolite identification. It emphasizes the applications of metabolite identification in drug research. While primarily a textbook, the book also functions as a comprehensive reference to...
| Автор-организации: | ebrary, Inc. |
|---|---|
| Други автори: | Lee, Mike S., 1960-, Zhu, Mingshe. |
| Формат: | Електронен |
| Език: | English |
| Публикувано: |
Hoboken, N.J. :
John Wiley & Sons,
c2011.
|
| Серия: |
Wiley series on pharmaceutical science and biotechnology: practices, applications and methods
|
| Предмети: | |
| Онлайн достъп: |
An electronic book accessible through the World Wide Web; click to view |
Съдържание:
- (Publisher-supplied data) Part I Basic Concepts of Drug Metabolism and Disposition
- The Progression of Drug Metabolism
- Common Biotransformation Reactions
- Metabolic Activation of Organic Functional Groups Utilized in Medicinal Chemistry
- Drug Metabolizing Enzymes, Transporters and Drug-Drug Interactions
- Experimental Models of Drug Metabolism and Disposition
- Principles of Pharmacokinetics: Predicting Human Pharmacokinetics
- Drug Metabolism Research as an Integral Part of the Drug Discovery and Development Processes
- Part II Mass Spectrometry in Drug Metabolism: Principles and Common Practice
- Theory and Instrumentation of Mass Spectrometry
- Common Liquid Chromatography-Mass Spectrometry (LC-MS) Methodology for Metabolite Identification
- Mass Spectral Interpretation
- Techniques to Facilitate the Performance of Mass Spectrometry: Sample Preparation, Liquid Chromatography and Non-Mass Spectrometric Detection
- Part III Applications of New LC/MS Techniques in Drug Metabolism and Disposition
- Quantitative In Vitro ADME Assays using LC-MS as a Part of Early Drug Metabolism Screening
- High Resolution Mass Spectrometry and Drug Metabolite Identification
- Distribution Studies of Drugs and Metabolites in Tissue by Mass Spectrometric Imaging
- Use of Triple Quadrupole-Linear Ion Trap Mass Spectrometry as a Single LC/MS Platform in Drug Metabolism and Pharmacokinetics Studies
- Quantitative Drug Metabolism with Accelerator Mass Spectrometry
- Standard-Free Estimation of Metabolite Levels Using Nanospray Mass Spectrometry: Current Statutes and Future Directions
- Profiling and Characterization of Herbal Medicine and their Metabolites using LC-MS
- Liquid Chromatography Mass Spectrometry Bioanalysis of Proteins in Biological Matrices
- Mass Spectrometry in the Analysis of DNA, Protein, Peptide, and Lipid Biomarkers of Oxidative Stress
- LC-MS in Endogenous Metabolite Profiling and Small Molecule Biomarker Discovery.