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Fluorine in pharmaceutical and medicinal chemistry from biophysical aspects to clinial applications /

Fluorine chemistry is an expanding area of research that is attracting international interest, due to the impact of fluorine in drug discovery and in clinical and molecular imaging (e.g. PET, MRI). Many researchers and academics are entering this area of research, while scientists in industrial and...

Пълно описание

Други автори: Gouverneur, Veronique., Mu˜ller, Klaus.
Формат: Електронен
Език: English
Публикувано: London : Singapore : Imperial College Press ; Dist. by World Scientific Press, 2012.
Серия: Molecular medicine and medicinal chemistry ; 6.
Предмети:
Онлайн достъп: http://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&AN=457253
Подобни документи: Print version:: Fluorine in pharmaceutical and medicinal chemistry.
Съдържание:
  • 1. Synthesis and properties of fluorinated nucleobases in DNA and RNA / Holger Gohlke, Jelena Bozilovic and Joachim W. Engels
  • 2. Molecular interactions of fluorinated amino acids within the hydrophobic core of a coiled coil peptide / Toni Vagt, Mario Salwiczek and Beate Koksch
  • 3. Probing the binding affinity and proteolytic stability of trifluoromethyl peptide mimics as protease inhibitors / Matteo Zanda [and others]
  • 4. Trifluoromethyl-substituted [symbol]-amino acids as solid-state [symbol]F NMR labels for structural studies of membrane-bound peptides / Vladimir S. Kubyshkin [and others]
  • 5. Fluorine-containing pharmaceuticals / Steve Swallow
  • 6. Applications of pentafluorosulfanyl substitution in life sciences research / John T. Welch
  • 7. Strategic incorporation of fluorine into taxoid anticancer agents / Antonella Pepe, Liang Sun and Iwao Ojima
  • 8. Synthesis and antiviral, antitumour activities of fluorinated sugar nucleosides / Feng Zheng, Xiao-Long Qiu and Feng-Ling Qing
  • 9. Synthesis of fluorinated neurotransmitter analogues / Margit Winkler and David O'Hagan
  • 10. [symbol]F-radionuclide chemistry / Romain Bejot and Veronique Gouverneur
  • 11. [symbol]F-labelled tracers for PET oncology and neurology applications / Sajinder K. Luthra and Edward G. Robins
  • 12. [symbol]F NMR: clinical and molecular imaging applications / Vikram D. Kodibagkar [and others].