A Mathematical Approach to Multilevel, Multiscale Health Interventions : Pharmaceutical Industry Decline and Policy Response.
This book, based on published studies, takes a unique perspective on the 30-year collapse of pharmaceutical industry productivity in the search for small molecule "magic bullet" interventions. The relentless escalation of inflation-adjusted cost per approved medicine in the United States -...
| Основен автор: | Wallace, Rodrick. |
|---|---|
| Други автори: | Wallace, Deborah. |
| Формат: | Електронна книга |
| Език: | English |
| Публикувано: |
Singapore :
World Scientific Publishing Company,
2013.
|
| Предмети: | |
| Онлайн достъп: |
http://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&AN=564487 |
Съдържание:
- 1. Beyond magic bullets. 1.1. The pharmaceutical catastrophe. 1.2. A new perspective. 1.3. Cognition as 'language'. 1.4. The human cognome
- 2. Expanding the theory. 2.1. No free lunch. 2.2. Multiple broadcasts, punctuated detection. 2.3. Metabolic constraints. 2.4. Environmental signals
- 3. Dynamic 'regression' models. 3.1. The simplest approach. 3.2. A rate distortion reformulation. 3.3. Multiple time scales. 3.4. Incoming information. 3.5. Pathologies. 3.6. Refining the model
- 4. An evolutionary excursion. 4.1. Introduction. 4.2. Ecosystems as information sources. 4.3. Genetic heritage. 4.4. Gene expression. 4.5. Interacting information sources. 4.6. Conclusions
- 5. Example: mental disorders. 5.1. Introduction. 5.2. Two classes. 5.3. Global broadcast models. 5.4. Gene expression. 5.5. Summary
- 6. Example: protein folding. 6.1. Introduction. 6.2. Spontaneous symmetry breaking. 6.3. A formal approach. 6.4. The energy picture. 6.5. The developmental picture. 6.6. A comprehensive treatment. 6.7. Aging and protein folding. 6.8. Summary
- 7. Example: glycome determinants. 7.1. Introduction. 7.2. Stochastic topology. 7.3. The glycomic conundrum. 7.4. Another cognitive paradigm. 7.5. Regulating glycan determinants. 7.6. Glycan spectra. 7.7. Summary
- 8. Example: glycan/lectin logic gates. 8.1. Introduction. 8.2. The critical exponent. 8.3. Two examples. 8.4. Information catalysis. 8.5. A tiling symmetry model. 8.6. Summary
- 9. Example: IDP logic gates. 9.1. Introduction. 9.2. Symbolic dynamics of molecular switching. 9.3. Another dual information source. 9.4. Information catalysis. 9.5. Summary
- 10. Treatment. 10.1. The generalized retina. 10.2. Therapeutic efficacy. 10.3. Psychosocial stress. 10.4. Flight, fight, and helplessness. 10.5. Institutions as niche construction. 10.6. The hall of mirrors. 10.7. Side effects reconsidered
- 11. History and health. 11.1. Malaria and the Fulani. 11.2. The American catastrophe
- 12. Beyond Glasperlenspiel
- 13. Mathematical appendix. 13.1. The tuning theorem. 13.2. The rate distortion theorem. 13.3. Stochastic differential equations. 13.4. Morse theory. 13.5. Groupoids. 13.6. 'Biological' renormalization. 13.7. Large deviations.