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The dissertation reflects an interdisciplinary approach of research typical for the science of geography. For more than half a century Pernik Valley is known as one of the territories with the worst quality of atmospheric air in Bulgaria. According to a 2013 report of the European Environment Agency, Pernik is the city with the most polluted atmospheric air in Europe in terms of concentrations of fine particles (PM10). The scientific work is divided into four main chapters, which analyze the interrelationships between the anthropogenic activity and the state of the atmosphere in Pernik Valley for the period 1980 - 2009, as follows: 1. Land cover of Pernik Valley, 2. Quality of the atmospheric air, 3. Climatic features, 4. Health consequences for the people as a result of the air pollution in the valley. Scientific methods of cartography, landscape ecology, urban climatology, medical climatology, and air pollution bioclimatology have been used. Serious exceedances of the limit values of atmospheric pollutants in the 1980s and 1990s were identified as a consequence of the large industrialization and urbanization of the city of Pernik during the Communist regime in Bulgaria (1944-1989). The combination of heavily polluting air production, the lack of control of emissions and the climatic conditions of Pernik Valley led to a sustained trend related to respiratory diseases, which by 2007 ranked first among the total morbidity in the city
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